Assessment of exposure to metallic nanoparticles on marine and fresh water model organisms at cellular and genetic level.

Assessment of exposure to metallic nanoparticles on marine and fresh water model organisms at cellular and genetic level.

Despite the benefits of nanotechnology, concern is mounting that due to their unique physico-chemical properties, nanoparticles (NPs) may cause unknown biological effects with environmental and human health consequences. Bio-accumulation, bio-persistence, environmental fate and exposure effects remain to be evaluated. Here, the relationships between physico-chemical properties of metallic NPs and biological effects will be examined using two aquatic (one marine and one freshwater) model organisms. Characterisation of NP accumulation and consequent changes in morphology, development, gene and protein expression will provide a basis for the determination of safe concentrations, detectable exposure levels, and potential biomarkers for NP impact and environmental monitoring.

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Environmental Protection Agency 2008-EH-MS-2-S3
Lokesh Joshi

Keywords: Nanoparticles; Biological effects; Freshwater and Marine; Monitoring

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